Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention
S Karmakar, J Kay… - Rheumatic Disease …, 2010 - rheumatic.theclinics.com
Rheumatoid arthritis (RA) is a systemic disease process that is characterized by
inflammation of the synovial tissues lining the joints. Proliferation of synovial lining cells and
infiltration of inflammatory cells, including monocytes and activated leukocytes, into the joint
tissues results in formation of pannus tissue that covers the surfaces of articular cartilage
and bone 1 and produces proinflammatory factors that lead to destruction of cartilage and
bone matrix. A common and characteristic feature of RA is focal articular bone loss, or …
inflammation of the synovial tissues lining the joints. Proliferation of synovial lining cells and
infiltration of inflammatory cells, including monocytes and activated leukocytes, into the joint
tissues results in formation of pannus tissue that covers the surfaces of articular cartilage
and bone 1 and produces proinflammatory factors that lead to destruction of cartilage and
bone matrix. A common and characteristic feature of RA is focal articular bone loss, or …