Osteoclasts are multinucleated cells with the unique ability to resorb bone. Elevated activity
of these cells under pathologic conditions leads to the progression of bone erosion that
occurs in osteoporosis, periodontal disease, and rheumatoid arthritis. Thus, the regulation of
osteoclast apoptosis is important for bone homeostasis. In this study, we examined the
effects of the Janus tyrosine kinase 2 specific inhibitor AG490 on osteoclast apoptosis. We
found that AG490 greatly inhibited osteoclast apoptosis. AG490 stimulated the …