PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction
Journal of Cell Biology, 2014•rupress.org
Abbreviations used in this paper: FMI, forward migration index; HGF, hepatocyte growth
factor; HM, hydrophobic motif; MLC2, myosin regulatory light chain 2; MRCK, myotonic
dystrophy kinase–related CDC42-binding kinase; MyPT1, myosin phosphatase target
subunit 1; PDK1, 3-phosphoinositide–dependent kinase 1; PH, pleckstrin homology; PI3K,
phosphatidylinositol 3 kinase; PIF, PDK1-interacting fragment; PIP3, phosphatidylinositol (3,
4, 5)-trisphosphate; PLA, proximity ligation assay; ROCK, Rho-associated protein kinase; …
factor; HM, hydrophobic motif; MLC2, myosin regulatory light chain 2; MRCK, myotonic
dystrophy kinase–related CDC42-binding kinase; MyPT1, myosin phosphatase target
subunit 1; PDK1, 3-phosphoinositide–dependent kinase 1; PH, pleckstrin homology; PI3K,
phosphatidylinositol 3 kinase; PIF, PDK1-interacting fragment; PIP3, phosphatidylinositol (3,
4, 5)-trisphosphate; PLA, proximity ligation assay; ROCK, Rho-associated protein kinase; …
Abbreviations used in this paper: FMI, forward migration index; HGF, hepatocyte growth factor; HM, hydrophobic motif; MLC2, myosin regulatory light chain 2; MRCK, myotonic dystrophy kinase–related CDC42-binding kinase; MyPT1, myosin phosphatase target subunit 1; PDK1, 3-phosphoinositide–dependent kinase 1; PH, pleckstrin homology; PI3K, phosphatidylinositol 3 kinase; PIF, PDK1-interacting fragment; PIP3, phosphatidylinositol (3, 4, 5)-trisphosphate; PLA, proximity ligation assay; ROCK, Rho-associated protein kinase; TIRF, total internal reflection fluorescence; WT, wild type.
rupress.org
