MARVEL: a conserved domain involved in membrane apposition events
L Sánchez-Pulido, F Martı́n-Belmonte… - Trends in biochemical …, 2002 - cell.com
Trends in biochemical sciences, 2002•cell.com
MARVEL is a novel domain with a four transmembrane-helix architecture that has been
identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin
families. Association with specialized membrane microdomains has been reported for some
of these MARVEL domain-containing proteins. Their function could be related to cholesterol-
rich membrane apposition events in a variety of cellular processes, such as biogenesis of
vesicular transport carriers or tight junction regulation. The MARVEL domain appears to be …
identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin
families. Association with specialized membrane microdomains has been reported for some
of these MARVEL domain-containing proteins. Their function could be related to cholesterol-
rich membrane apposition events in a variety of cellular processes, such as biogenesis of
vesicular transport carriers or tight junction regulation. The MARVEL domain appears to be …
Abstract
MARVEL is a novel domain with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families. Association with specialized membrane microdomains has been reported for some of these MARVEL domain-containing proteins. Their function could be related to cholesterol-rich membrane apposition events in a variety of cellular processes, such as biogenesis of vesicular transport carriers or tight junction regulation. The MARVEL domain appears to be related to complex human diseases, such as schizophrenia and inflammation.
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