[HTML][HTML] Signal transduction by the JNK group of MAP kinases

RJ Davis - Cell, 2000 - cell.com
Cell, 2000cell.com
Cells respond to changes in the physical and chemical properties of the environment. These
changes include alterations in the amount of nutrients, growth factors, cytokines, and
adhesion to the cell matrix. In addition, cells respond to physical stimulation mediated by
osmolarity, heat, pH, redox, radiation, and mechanical stress. These physical and chemical
cues control many aspects of cell function including migration, proliferation, differentiation,
and death. The decision making process that cells employ to mount an appropriate …
Cells respond to changes in the physical and chemical properties of the environment. These changes include alterations in the amount of nutrients, growth factors, cytokines, and adhesion to the cell matrix. In addition, cells respond to physical stimulation mediated by osmolarity, heat, pH, redox, radiation, and mechanical stress. These physical and chemical cues control many aspects of cell function including migration, proliferation, differentiation, and death. The decision making process that cells employ to mount an appropriate response to a specific stimulus is critical for normal life. Many signal transduction pathways cooperate and participate in this process. Recent studies have established that mitogen-activated protein kinases (MAPK) play an important regulatory role.
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