[HTML][HTML] The NF-κB pathway and cancer stem cells

AL Rinkenbaugh, AS Baldwin - Cells, 2016 - mdpi.com
AL Rinkenbaugh, AS Baldwin
Cells, 2016mdpi.com
The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune
responses. Additionally, aberrant NF-κB signaling has been identified in many types of
cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB
regulates transcription of target genes that promote cell survival and proliferation, inhibit
apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a
subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment …
The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-κB signaling in cancer stem cell biology.
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