Insulin resistance in adipose tissue increases the release of free fatty acids into the
circulation, which likely contributes to impaired insulin action in liver and skeletal muscle
associated with obesity. However, reliable assessment of adipose tissue insulin resistance
requires performing a hyperinsulinemic-euglycemic clamp procedure in conjunction with a
fatty acid tracer infusion to determine insulin-mediated suppression of lipolytic rate. We
developed a simpler method for evaluating adipose tissue insulin resistance in vivo …