[HTML][HTML] Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis

D Bhattacharya, VP Dwivedi, M Maiga, M Maiga… - Journal of Biological …, 2014 - ASBMB
Tuberculosis remains the biggest infectious threat to humanity with one-third of the
population infected and 1.4 million deaths and 8.7 million new cases annually. Current
tuberculosis therapy is lengthy and consists of multiple antimicrobials, which causes poor
compliance and high treatment dropout, resulting in the development of drug-resistant
variants of tuberculosis. Therefore, alternate methods to treat tuberculosis are urgently
needed. Mycobacterium tuberculosis evades host immune responses by inducing T helper …