FOXO1, T-cell trafficking and immune responses

F Carrette, S Fabre, G Bismuth - … Factors: Vital Elements in Biology and …, 2009 - Springer
F Carrette, S Fabre, G Bismuth
Forkhead Transcription Factors: Vital Elements in Biology and Medicine, 2009Springer
Efficient T-cell adaptive immune response require a faultless coordination between
migration of naive T-cells into secondary lymphoid organs and critical biological outcomes
driven by antigen such as cell division and cell differentiation into effector and memory cells.
Recent works have shown that the phosphoinositide 3-kinase (PI3K) pathway could govern
several of these processes. In this control, transcriptional factors of the Forkhead box O
(FoxO) family, in particular FOXO1, a downstream effector ofPI3K, appears to play a major …
Abstract
Efficient T-cell adaptive immune response require a faultless coordination between migration of naive T-cells into secondary lymphoid organs and critical biological outcomes driven by antigen such as cell division and cell differentiation into effector and memory cells. Recent works have shown that the phosphoinositide 3-kinase (PI3K) pathway could govern several of these processes. In this control, transcriptional factors of the Forkhead box O (FoxO) family, in particular FOXO1, a downstream effector ofPI3K, appears to play a major role by coordinating both cellular proliferation of T-cells after antigen recognition and expression of homing molecules essential for their trafficking in the body.
Springer