[HTML][HTML] STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors
Much is known about the role of STAT3 in regulating differentiation of interleukin-17-
producing Th17 cells, but its function in other lymphocyte subsets is not well understood. In
this report, we reveal wide-ranging functions of STAT3 in T-cells and provide evidence that
STAT3 is convergence point for mechanisms that regulate lymphocyte quiescence and
those controlling T-cell activation and survival. We show here that STAT3 inhibits T-
lymphocyte proliferation by up-regulating the expression of Class-O Forkhead transcription …
producing Th17 cells, but its function in other lymphocyte subsets is not well understood. In
this report, we reveal wide-ranging functions of STAT3 in T-cells and provide evidence that
STAT3 is convergence point for mechanisms that regulate lymphocyte quiescence and
those controlling T-cell activation and survival. We show here that STAT3 inhibits T-
lymphocyte proliferation by up-regulating the expression of Class-O Forkhead transcription …
