[HTML][HTML] The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane …
F Orsini, E Migliaccio, M Moroni, C Contursi… - Journal of Biological …, 2004 - ASBMB
P66Shc regulates life span in mammals and is a critical component of the apoptotic
response to oxidative stress. It functions as a downstream target of the tumor suppressor p53
and is indispensable for the ability of oxidative stress-activated p53 to induce apoptosis. The
molecular mechanisms underlying the apoptogenic effect of p66Shc are unknown. Here we
report the following three findings.(i) The apoptosome can be properly activated in vitro in
the absence of p66Shc only if purified cytochrome c is supplied.(ii) Cytochrome c release …
response to oxidative stress. It functions as a downstream target of the tumor suppressor p53
and is indispensable for the ability of oxidative stress-activated p53 to induce apoptosis. The
molecular mechanisms underlying the apoptogenic effect of p66Shc are unknown. Here we
report the following three findings.(i) The apoptosome can be properly activated in vitro in
the absence of p66Shc only if purified cytochrome c is supplied.(ii) Cytochrome c release …