The comings and goings of PARP-1 in response to DNA damage
JM Pascal - DNA repair, 2018 - Elsevier
Abstract Poly (ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA
damage response, acting as a first responder that detects DNA strand breaks, and
contributes to repair pathway choice and the efficiency of repair through modulation of
chromatin structure and through interaction with and modification of a multitude of DNA
repair factors. This perspective summarizes our knowledge of PARP-1 involvement in DNA …
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA
damage response, acting as a first responder that detects DNA strand breaks, and
contributes to repair pathway choice and the efficiency of repair through modulation of
chromatin structure and through interaction with and modification of a multitude of DNA
repair factors. This perspective summarizes our knowledge of PARP-1 involvement in DNA …