Poly (ADP-ribose) polymerase (PARP) is responsible for post-translational modification of
proteins in the response to numerous endogenous and environmental genotoxic agents.
PARP and poly (ADP-ribosyl) ation are proposed to be important for the regulation of many
cellular processes such as DNA repair, cell death, chromatin functions and genomic stability.
Activation of PARP is one of the early DNA damage responses, among other DNA sensing
molecules, such as DNA-PK, ATM and p53. The generation and characterization of PARP …