The development and function of regulatory T cells
CJ Workman, AL Szymczak-Workman… - Cellular and molecular …, 2009 - Springer
CJ Workman, AL Szymczak-Workman, LW Collison, MR Pillai, DAA Vignali
Cellular and molecular life sciences, 2009•SpringerRegulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance.
There are two types of Tregs: natural Tregs, which develop in the thymus, and induced
Tregs, which are derived from naive CD4+ T cells in the periphery. Tregs utilize a variety of
mechanisms to suppress the immune response. While Tregs are critical for the peripheral
maintenance of potential autoreactive T cells, they can also be detrimental by preventing
effective anti-tumor responses and sterilizing immunity against pathogens. In this review, we …
There are two types of Tregs: natural Tregs, which develop in the thymus, and induced
Tregs, which are derived from naive CD4+ T cells in the periphery. Tregs utilize a variety of
mechanisms to suppress the immune response. While Tregs are critical for the peripheral
maintenance of potential autoreactive T cells, they can also be detrimental by preventing
effective anti-tumor responses and sterilizing immunity against pathogens. In this review, we …
Abstract
Regulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance. There are two types of Tregs: natural Tregs, which develop in the thymus, and induced Tregs, which are derived from naive CD4+ T cells in the periphery. Tregs utilize a variety of mechanisms to suppress the immune response. While Tregs are critical for the peripheral maintenance of potential autoreactive T cells, they can also be detrimental by preventing effective anti-tumor responses and sterilizing immunity against pathogens. In this review, we will discuss the development of natural and induced Tregs as well as the role of Tregs in a variety of disease settings and the mechanisms they utilize for suppression.
Springer
