Severe pneumonia mortality in elderly patients is associated with downregulation of Toll-like receptors 2 and 4 on monocytes
L Tang, Q Li, J Bai, S Ma, H Zhang, Y Lu - The American journal of the …, 2014 - Elsevier
Background Elderly patients with pneumonia have a high mortality rate. Since Toll-like
receptor (TLR) signaling is involved in the inflammatory response, we conducted a
prospective observational case–control study to assess the relationships of TLR2 and TLR4
mortality with elderly patients with pneumonia. Methods Clinical and laboratory data were
collected from these elderly patients with pneumonia (patient group; n= 40) and healthy age-
matched subjects (control 1; n= 20). TLR2 and TLR4 expression levels on blood monocytes …
receptor (TLR) signaling is involved in the inflammatory response, we conducted a
prospective observational case–control study to assess the relationships of TLR2 and TLR4
mortality with elderly patients with pneumonia. Methods Clinical and laboratory data were
collected from these elderly patients with pneumonia (patient group; n= 40) and healthy age-
matched subjects (control 1; n= 20). TLR2 and TLR4 expression levels on blood monocytes …