[HTML][HTML] Preclinical animal models of multiple myeloma
ST Lwin, CM Edwards, R Silbermann - BoneKEy reports, 2016 - ncbi.nlm.nih.gov
ST Lwin, CM Edwards, R Silbermann
BoneKEy reports, 2016•ncbi.nlm.nih.govMultiple myeloma is an incurable plasma-cell malignancy characterized by osteolytic bone
disease and immunosuppression. Murine models of multiple myeloma and myeloma bone
disease are critical tools for an improved understanding of the pathogenesis of the disease
and the development of novel therapeutic strategies. This review will cover commonly used
immunocompetent and xenograft models of myeloma, describing the advantages and
disadvantages of each model system. In addition, this review provides detailed protocols for …
disease and immunosuppression. Murine models of multiple myeloma and myeloma bone
disease are critical tools for an improved understanding of the pathogenesis of the disease
and the development of novel therapeutic strategies. This review will cover commonly used
immunocompetent and xenograft models of myeloma, describing the advantages and
disadvantages of each model system. In addition, this review provides detailed protocols for …
Abstract
Multiple myeloma is an incurable plasma-cell malignancy characterized by osteolytic bone disease and immunosuppression. Murine models of multiple myeloma and myeloma bone disease are critical tools for an improved understanding of the pathogenesis of the disease and the development of novel therapeutic strategies. This review will cover commonly used immunocompetent and xenograft models of myeloma, describing the advantages and disadvantages of each model system. In addition, this review provides detailed protocols for establishing systemic and local models of myeloma using both murine and human myeloma cell lines.
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