[PDF][PDF] SnapShot: T cell exhaustion

KE Pauken, EJ Wherry - Cell, 2015 - cell.com
Cell, 2015cell.com
Exhaustion is a state of T cell differentiation common during chronic infection and cancer
that results in T cell dysfunction. Exhausted T cells (T EX) progressively lose effector
functions and develop defects in memory T cell properties due to exposure to persistent
antigen and inflammation. Exhaustion can be reversed, at least partially, by blocking
inhibitory pathways such as PD-1, resulting in improved pathogen or tumor control. To view
this SnapShot, open or download the PDF.
Exhaustion is a state of T cell differentiation common during chronic infection and cancer that results in T cell dysfunction. Exhausted T cells (TEX) progressively lose effector functions and develop defects in memory T cell properties due to exposure to persistent antigen and inflammation. Exhaustion can be reversed, at least partially, by blocking inhibitory pathways such as PD-1, resulting in improved pathogen or tumor control. To view this SnapShot, open or download the PDF.
cell.com