Nickel induces intracellular calcium mobilization and pathophysiological responses in human cultured airway epithelial cells
J Cortijo, J Milara, M Mata, E Donet, N Gavara… - Chemico-biological …, 2010 - Elsevier
Environmental exposure to nickel is associated to respiratory disorders and potential toxicity
in the lung but molecular mechanisms remain incompletely explored. The extracellular Ca2+-
sensing receptor (CaSR) is widely distributed and may be activated by divalent cations. In
this study, we investigated the presence of CaSR in human cultured airway epithelial cells
and its activation by nickel. Nickel transiently increased intracellular calcium (− logEC50=
4.67±0.06) in A549 and human bronchial epithelial cells as measured by epifluorescence …
in the lung but molecular mechanisms remain incompletely explored. The extracellular Ca2+-
sensing receptor (CaSR) is widely distributed and may be activated by divalent cations. In
this study, we investigated the presence of CaSR in human cultured airway epithelial cells
and its activation by nickel. Nickel transiently increased intracellular calcium (− logEC50=
4.67±0.06) in A549 and human bronchial epithelial cells as measured by epifluorescence …