Apelin reduces myocardial reperfusion injury independently of PI3K/Akt and P70S6 kinase
MJ Kleinz, GF Baxter - Regulatory peptides, 2008 - Elsevier
Apelin, the endogenous ligand of the G protein-coupled APJ receptor, is a peptide mediator
with emerging regulatory actions in the heart. The aim of the present studies was to explore
potential roles of the apelin/APJ system in myocardial ischaemia/reperfusion injury. To
determine the cardiac expression of apelin/APJ and potential regulation by acute ischaemic
insult, Langendorff perfused rat hearts were subjected to regional ischaemia (left coronary
artery occlusion, 35 min) or ischaemia followed by reperfusion (30 min). Apelin and APJ …
with emerging regulatory actions in the heart. The aim of the present studies was to explore
potential roles of the apelin/APJ system in myocardial ischaemia/reperfusion injury. To
determine the cardiac expression of apelin/APJ and potential regulation by acute ischaemic
insult, Langendorff perfused rat hearts were subjected to regional ischaemia (left coronary
artery occlusion, 35 min) or ischaemia followed by reperfusion (30 min). Apelin and APJ …