[HTML][HTML] Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression
CA Piantadosi, CM Withers, RR Bartz… - Journal of Biological …, 2011 - ASBMB
The induction of heme oxygenase-1 (HO-1; Hmox1) by inflammation, for instance in sepsis,
is associated both with an anti-inflammatory response and with mitochondrial biogenesis.
Here, we tested the idea that HO-1, acting through the Nfe2l2 (Nrf2) transcription factor, links
anti-inflammatory cytokine expression to activation of mitochondrial biogenesis. HO-1
induction after LPS stimulated anti-inflammatory IL-10 and IL-1 receptor antagonist (IL-1Ra)
expression in mouse liver, human HepG2 cells, and mouse J774. 1 macrophages but …
is associated both with an anti-inflammatory response and with mitochondrial biogenesis.
Here, we tested the idea that HO-1, acting through the Nfe2l2 (Nrf2) transcription factor, links
anti-inflammatory cytokine expression to activation of mitochondrial biogenesis. HO-1
induction after LPS stimulated anti-inflammatory IL-10 and IL-1 receptor antagonist (IL-1Ra)
expression in mouse liver, human HepG2 cells, and mouse J774. 1 macrophages but …
