[HTML][HTML] Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction*♦

DA Kubli, X Zhang, Y Lee, RA Hanna… - Journal of Biological …, 2013 - ASBMB
It is known that loss-of-function mutations in the gene encoding Parkin lead to development
of Parkinson disease. Recently, Parkin was found to play an important role in the removal of
dysfunctional mitochondria via autophagy in neurons. Although Parkin is expressed in the
heart, its functional role in this tissue is largely unexplored. In this study, we have
investigated the role of Parkin in the myocardium under normal physiological conditions and
in response to myocardial infarction. We found that Parkin-deficient (Parkin−/−) mice had …