Novel, non-peptidic somatostatin receptor subtype 5 antagonists improve glucose tolerance in rodents

U Sprecher, P Mohr, RE Martin, HP Maerki… - Regulatory peptides, 2010 - Elsevier
BACKGROUND: Somatostatin regulates numerous endocrine processes, including glucose
homeostasis. The contribution and effects of the 5 somatostatin receptors are still unclear, in
part due to the lack of suitable subtype specific receptor antagonists. We explored the effects
of two novel, non-peptidic, orally bioavailable somatostatin receptor subtype 5 antagonists
named Compound A and Compound B on glycemia in animal models of type 2 diabetes
after an initial in vitro characterization. METHODS AND RESULTS: Compound A led to a …