Tumor microenvironment heterogeneity: challenges and opportunities
F Runa, S Hamalian, K Meade, P Shisgal… - Current molecular …, 2017 - Springer
Current molecular biology reports, 2017•Springer
The tumor microenvironment (TME) has been recognized as an integral component of
malignancies in breast and prostate tissues, contributing in confounding ways to tumor
progression, metastasis, therapy resistance, and disease recurrence. Major components of
the TME are immune cells, fibroblasts, pericytes, endothelial cells, mesenchymal
stroma/stem cells (MSCs), and extracellular matrix (ECM) components. Herein, we discuss
the molecular and cellular heterogeneity within the TME and how this presents unique …
malignancies in breast and prostate tissues, contributing in confounding ways to tumor
progression, metastasis, therapy resistance, and disease recurrence. Major components of
the TME are immune cells, fibroblasts, pericytes, endothelial cells, mesenchymal
stroma/stem cells (MSCs), and extracellular matrix (ECM) components. Herein, we discuss
the molecular and cellular heterogeneity within the TME and how this presents unique …
Abstract
The tumor microenvironment (TME) has been recognized as an integral component of malignancies in breast and prostate tissues, contributing in confounding ways to tumor progression, metastasis, therapy resistance, and disease recurrence. Major components of the TME are immune cells, fibroblasts, pericytes, endothelial cells, mesenchymal stroma/stem cells (MSCs), and extracellular matrix (ECM) components. Herein, we discuss the molecular and cellular heterogeneity within the TME and how this presents unique challenges and opportunities for treating breast and prostate cancers.
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