[HTML][HTML] Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1. 3
L Lu, P Sirish, Z Zhang, RL Woltz, N Li… - Journal of Biological …, 2015 - ASBMB
Ca v 1.3 L-type Ca 2+ channel is known to be highly expressed in neurons and
neuroendocrine cells. However, we have previously demonstrated that the Ca v 1.3 channel
is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-
specific expression of the channel is underpinned by our previous demonstration of atrial
fibrillation in a Ca v 1.3 null mutant mouse model. Indeed, a recent study has confirmed the
critical roles of Ca v 1.3 in the human heart (Baig, SM, Koschak, A., Lieb, A., Gebhart, M …
neuroendocrine cells. However, we have previously demonstrated that the Ca v 1.3 channel
is also expressed in atria and pacemaking cells in the heart. The significance of the tissue-
specific expression of the channel is underpinned by our previous demonstration of atrial
fibrillation in a Ca v 1.3 null mutant mouse model. Indeed, a recent study has confirmed the
critical roles of Ca v 1.3 in the human heart (Baig, SM, Koschak, A., Lieb, A., Gebhart, M …