[HTML][HTML] Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis
AA Bouza, JM Philippe, N Edokobi, AM Pinsky… - Journal of Biological …, 2020 - ASBMB
Voltage-gated sodium channel (VGSC) β1 subunits are multifunctional proteins that
modulate the biophysical properties and cell-surface localization of VGSC α subunits and
participate in cell–cell and cell–matrix adhesion, all with important implications for
intracellular signal transduction, cell migration, and differentiation. Human loss-of-function
variants in SCN1B, the gene encoding the VGSC β1 subunits, are linked to severe diseases
with high risk for sudden death, including epileptic encephalopathy and cardiac arrhythmia …
modulate the biophysical properties and cell-surface localization of VGSC α subunits and
participate in cell–cell and cell–matrix adhesion, all with important implications for
intracellular signal transduction, cell migration, and differentiation. Human loss-of-function
variants in SCN1B, the gene encoding the VGSC β1 subunits, are linked to severe diseases
with high risk for sudden death, including epileptic encephalopathy and cardiac arrhythmia …