Many immunoglobulin superfamily members are integral in development through regulation
of processes such as growth cone guidance, cell migration, and neurite outgrowth. We
demonstrate that homophilic interactions between voltage-gated sodium channel β1
subunits promote neurite extension in cerebellar granule neurons. Neurons isolated from
wild-type or β1 (-/-) mice were plated on top of parental, mock-, or β1-transfected fibroblasts.
Wild-type neurons consistently showed increased neurite length when grown on β1 …