Nuclear expression of phosphorylated TRAF2-and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis
J Jin, HY Jung, Y Wang, J Xie, YI Yeom, JJ Jang… - … -Research and Practice, 2014 - Elsevier
Background and aims TRAF2-and NCK-interacting kinase (TNIK) is a member of the
germinal center kinase family and a transcription factor 4 (TCF4) interactor is recruited to
promoters of Wnt target genes via phosphorylation of the TCF/β-catenin complex. The aim of
this study was to evaluate the TNIK, the active form of TNIK (p-TNIK), and β-catenin
expression in hepatocellular carcinoma (HCC), and to identify the prognostic significance of
p-TNIK. Methods We assessed the expression status of TNIK, p-TNIK, and β-catenin by …
germinal center kinase family and a transcription factor 4 (TCF4) interactor is recruited to
promoters of Wnt target genes via phosphorylation of the TCF/β-catenin complex. The aim of
this study was to evaluate the TNIK, the active form of TNIK (p-TNIK), and β-catenin
expression in hepatocellular carcinoma (HCC), and to identify the prognostic significance of
p-TNIK. Methods We assessed the expression status of TNIK, p-TNIK, and β-catenin by …