[HTML][HTML] Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein α and peroxisome proliferator …
Mesenchymal precursor cells have the potential to differentiate into several cell types,
including adipocytes and osteoblasts. Activation of Wnt/β-catenin signaling shifts
mesenchymal cell fate toward osteoblastogenesis at the expense of adipogenesis; however,
molecular mechanisms by which Wnt signaling alters mesenchymal cell fate have not been
fully investigated. Our prior work indicates that multipotent precursors express adipogenic
and osteoblastogenic transcription factors at physiological levels and that ectopic …
including adipocytes and osteoblasts. Activation of Wnt/β-catenin signaling shifts
mesenchymal cell fate toward osteoblastogenesis at the expense of adipogenesis; however,
molecular mechanisms by which Wnt signaling alters mesenchymal cell fate have not been
fully investigated. Our prior work indicates that multipotent precursors express adipogenic
and osteoblastogenic transcription factors at physiological levels and that ectopic …