[HTML][HTML] Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1
Y Rouillé, S Kantengwa, JC Irminger… - Journal of Biological …, 1997 - ASBMB
Proglucagon is processed differentially in pancreatic α-cells and intestinal endocrine L cells
to release either glucagon or glucagon-like peptide-1-(7–36amide)(tGLP-1), two peptide
hormones with opposing biological actions. Previous studies have demonstrated that the
prohormone convertase PC2 is responsible for the processing of proglucagon to glucagon,
and have suggested that the related endoprotease PC3 is involved in the formation of tGLP-
1. To understand better the biosynthetic pathway of tGLP-1, proglucagon processing was …
to release either glucagon or glucagon-like peptide-1-(7–36amide)(tGLP-1), two peptide
hormones with opposing biological actions. Previous studies have demonstrated that the
prohormone convertase PC2 is responsible for the processing of proglucagon to glucagon,
and have suggested that the related endoprotease PC3 is involved in the formation of tGLP-
1. To understand better the biosynthetic pathway of tGLP-1, proglucagon processing was …