Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)–deficient mice
PA Verhoef, MG Constantinides, BD McDonald… - Journal of Allergy and …, 2016 - Elsevier
Background The transcription factor promyelocytic leukemia zinc finger (PLZF) is transiently
expressed during development of type 2 innate lymphoid cells (ILC2s) but is not present at
the mature stage. We hypothesized that PLZF-deficient ILC2s have functional defects in the
innate allergic response and represent a tool for studying innate immunity in a mouse with a
functional adaptive immune response. Objective We determined the consequences of PLZF
deficiency on ILC2 function in response to innate and adaptive immune stimuli by using …
expressed during development of type 2 innate lymphoid cells (ILC2s) but is not present at
the mature stage. We hypothesized that PLZF-deficient ILC2s have functional defects in the
innate allergic response and represent a tool for studying innate immunity in a mouse with a
functional adaptive immune response. Objective We determined the consequences of PLZF
deficiency on ILC2 function in response to innate and adaptive immune stimuli by using …