Activated plasmacytoid dendritic cells regulate type 2 innate lymphoid cell–mediated airway hyperreactivity
H Maazi, H Banie, GRA Muench, N Patel… - Journal of Allergy and …, 2018 - Elsevier
Background Allergic asthma is a prevalent inflammatory disease of the airways caused by
dysregulated immune balance in the lungs with incompletely understood pathogenesis. The
recently identified type 2 innate lymphoid cells (ILC2s) play significant roles in the
pathogenesis of asthma. Although ILC2-activating factors have been identified, the
mechanisms that suppress ILC2s remain largely unknown. Plasmacytoid dendritic cells
(pDCs) are important in antiviral immunity and in maintaining tolerance to inert antigens …
dysregulated immune balance in the lungs with incompletely understood pathogenesis. The
recently identified type 2 innate lymphoid cells (ILC2s) play significant roles in the
pathogenesis of asthma. Although ILC2-activating factors have been identified, the
mechanisms that suppress ILC2s remain largely unknown. Plasmacytoid dendritic cells
(pDCs) are important in antiviral immunity and in maintaining tolerance to inert antigens …