Toll-like receptor 9–dependent interferon production prevents group 2 innate lymphoid cell–driven airway hyperreactivity
CLP Thio, ACY Lai, PY Chi, G Webster… - Journal of Allergy and …, 2019 - Elsevier
Background Group 2 innate lymphoid cells (ILC2s) are important mediators of allergic
asthma. Bacterial components, such as unmethylated CpG DNA, a Toll-like receptor (TLR) 9
agonist, are known to possess beneficial immunomodulatory effects in patients with T cell–
mediated chronic asthma. However, their roles in regulating ILC2s remain unclear. Objective
We sought to determine the role of TLR9 activation in regulating ILC2 function and to
evaluate the therapeutic utility of an immunomodulatory microparticle containing natural …
asthma. Bacterial components, such as unmethylated CpG DNA, a Toll-like receptor (TLR) 9
agonist, are known to possess beneficial immunomodulatory effects in patients with T cell–
mediated chronic asthma. However, their roles in regulating ILC2s remain unclear. Objective
We sought to determine the role of TLR9 activation in regulating ILC2 function and to
evaluate the therapeutic utility of an immunomodulatory microparticle containing natural …
