Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

TYF Halim, YY Hwang, ST Scanlon, H Zaghouani… - Nature …, 2016 - nature.com
TYF Halim, YY Hwang, ST Scanlon, H Zaghouani, N Garbi, PG Fallon, ANJ McKenzie
Nature immunology, 2016nature.com
Rapid activation of memory CD4+ T helper 2 (TH2) cells during allergic inflammation
requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate
lymphoid (ILC2) cells have a crucial role in memory TH2 cell responses, with targeted
depletion of ILC2 cells profoundly impairing TH2 cell localization to the lungs and skin of
sensitized mice after allergen re-challenge. ILC2-derived interleukin 13 (IL-13) is critical for
eliciting production of the TH2 cell–attracting chemokine CCL17 by IRF4+ CD11b+ CD103 …
Abstract
Rapid activation of memory CD4+ T helper 2 (TH2) cells during allergic inflammation requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate lymphoid (ILC2) cells have a crucial role in memory TH2 cell responses, with targeted depletion of ILC2 cells profoundly impairing TH2 cell localization to the lungs and skin of sensitized mice after allergen re-challenge. ILC2-derived interleukin 13 (IL-13) is critical for eliciting production of the TH2 cell–attracting chemokine CCL17 by IRF4+CD11b+CD103 dendritic cells (DCs). Consequently, the sentinel function of DCs is contingent on ILC2 cells for the generation of an efficient memory TH2 cell response. These results elucidate a key innate mechanism in the regulation of the immune memory response to allergens.
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