[HTML][HTML] Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention
F1000Research, 2019•ncbi.nlm.nih.gov
Vascular tumors are neoplasms of endothelial cells, a significant number of which present in
childhood. Recent studies have examined the mutational landscape of many subtypes of
vascular tumors, identifying mutations primarily within the Ras–mitogen-activated protein
kinase (MAPK) pathway and providing a unique opportunity to consider targeted
therapeutics. This review will summarize the current understanding of childhood vascular
tumor pathobiology.
childhood. Recent studies have examined the mutational landscape of many subtypes of
vascular tumors, identifying mutations primarily within the Ras–mitogen-activated protein
kinase (MAPK) pathway and providing a unique opportunity to consider targeted
therapeutics. This review will summarize the current understanding of childhood vascular
tumor pathobiology.
Abstract
Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras–mitogen-activated protein kinase (MAPK) pathway and providing a unique opportunity to consider targeted therapeutics. This review will summarize the current understanding of childhood vascular tumor pathobiology.
ncbi.nlm.nih.gov