Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice
MJ Polanczyk, C Hopke, J Huan… - Journal of …, 2005 - Elsevier
Estrogen (E2) upregulates the FoxP3 gene that marks regulatory CD4+ CD25+ T cells (Treg
cells). However, E2 also inhibits the ability of antigen presenting cells (APC) to activate T
cells. It is possible that these opposing functions might affect the degree of overt suppression
during pregnancy and autoimmunity. To evaluate E2 effects on Treg cell function, we
quantified FoxP3 levels and Treg suppression in CD4+ CD25+ T cells from pregnant and E2-
treated mice, and overt Treg suppression in E2-vs. placebo-pretreated mice with …
cells). However, E2 also inhibits the ability of antigen presenting cells (APC) to activate T
cells. It is possible that these opposing functions might affect the degree of overt suppression
during pregnancy and autoimmunity. To evaluate E2 effects on Treg cell function, we
quantified FoxP3 levels and Treg suppression in CD4+ CD25+ T cells from pregnant and E2-
treated mice, and overt Treg suppression in E2-vs. placebo-pretreated mice with …