OBJECTIVE: To examine the presence of gender differences in pulmonary inflammation
evoked by acute systemic cadmium administration in rats. METHODS: Presence of basic
indicators of lung inflammation (inflammatory cytokine lung content, leukocyte infiltration and
activity of cells recovered from lungs by enzyme digestion) was analyzed and compared in
animals of the two sexes. RESULTS: Intraperitoneal administration of cadmium (1.0 mg/kg)
resulted in higher cadmium content in lungs of female rats. Higher tumor necrosis factor …