Prostaglandin E2 and stem cell factor can deliver opposing signals to B lymphocyte precursors

T Shimozato, PW Kincade - Cellular immunology, 1999 - Elsevier
The synthetic prostanoid, 16, 16-dimethyl PGE2, suppressed B lymphopoiesis in mice and
proliferation of normal B cell precursors or the F10 pro-B cell line to interleukin 7 in culture.
This was not the case with two other prostanoids, PGD2 and PGF2α, or agonists for PGI2
agonist and thromboxane A2 agonist receptors. PGE2, but not the related prostanoids or
agonists, induced apoptosis in F10 cells. The apoptotic response was mediated by the EP2
class of PGE2 receptors and required an increase in intracellular cyclic adenosine 3′, 5 …