Inflammation: a key regulator of hematopoietic stem cell fate in health and disease
EM Pietras - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Blood, The Journal of the American Society of Hematology, 2017•ashpublications.org
Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the
same time, they must respond rapidly to acute needs such as infection or injury. Significant
interest has emerged in how inflammation regulates HSC fate and how it affects the long-
term functionality of HSCs and the blood system as a whole. Here we detail recent advances
and unanswered questions at the intersection between inflammation and HSC biology in the
contexts of development, aging, and hematological malignancy.
same time, they must respond rapidly to acute needs such as infection or injury. Significant
interest has emerged in how inflammation regulates HSC fate and how it affects the long-
term functionality of HSCs and the blood system as a whole. Here we detail recent advances
and unanswered questions at the intersection between inflammation and HSC biology in the
contexts of development, aging, and hematological malignancy.
Abstract
Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the same time, they must respond rapidly to acute needs such as infection or injury. Significant interest has emerged in how inflammation regulates HSC fate and how it affects the long-term functionality of HSCs and the blood system as a whole. Here we detail recent advances and unanswered questions at the intersection between inflammation and HSC biology in the contexts of development, aging, and hematological malignancy.
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