Signaling via Toll-like receptor 5 can initiate inflammatory mediator production by murine osteoblasts
DR Madrazo, SL Tranguch, I Marriott - Infection and immunity, 2003 - Am Soc Microbiol
DR Madrazo, SL Tranguch, I Marriott
Infection and immunity, 2003•Am Soc MicrobiolMurine osteoblasts express Toll-like receptor 5 (TLR5), and this expression is upregulated
following exposure to bacteria or to the TLR5 agonist, flagellin. Importantly, flagellin
activates transcriptional regulators and elicits proinflammatory cytokine production,
suggesting TLR5 functionality. TLR5 may represent an important mechanism underlying the
recognition of bacterial pathogens by osteoblasts during bone infections.
following exposure to bacteria or to the TLR5 agonist, flagellin. Importantly, flagellin
activates transcriptional regulators and elicits proinflammatory cytokine production,
suggesting TLR5 functionality. TLR5 may represent an important mechanism underlying the
recognition of bacterial pathogens by osteoblasts during bone infections.
Abstract
Murine osteoblasts express Toll-like receptor 5 (TLR5), and this expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Importantly, flagellin activates transcriptional regulators and elicits proinflammatory cytokine production, suggesting TLR5 functionality. TLR5 may represent an important mechanism underlying the recognition of bacterial pathogens by osteoblasts during bone infections.
American Society for Microbiology