AMPK mediates the initiation of kidney disease induced by a high-fat diet
AE Decleves, AV Mathew, R Cunard… - Journal of the American …, 2011 - journals.lww.com
The mechanisms underlying the association between obesity and progressive renal disease
are not well understood. Exposure to a high-fat diet decreases levels of the cellular energy
sensor AMPK in many organs, including the kidney, but whether AMPK contributes to the
pathophysiology of kidney disease induced by a high-fat diet is unknown. In this study, we
randomly assigned C57BL/6J mice to a standard or high-fat diet. After 1 week, mice fed a
high-fat diet exhibited an increase in body weight, renal hypertrophy, an increase in urine H …
are not well understood. Exposure to a high-fat diet decreases levels of the cellular energy
sensor AMPK in many organs, including the kidney, but whether AMPK contributes to the
pathophysiology of kidney disease induced by a high-fat diet is unknown. In this study, we
randomly assigned C57BL/6J mice to a standard or high-fat diet. After 1 week, mice fed a
high-fat diet exhibited an increase in body weight, renal hypertrophy, an increase in urine H …