[HTML][HTML] Hydrogen Sulfide Inhibits High Glucose-induced Matrix Protein Synthesis by Activating AMP-activated Protein Kinase in Renal Epithelial Cells*♦
HJ Lee, MM Mariappan, D Feliers… - Journal of Biological …, 2012 - ASBMB
Hydrogen sulfide, a signaling gas, affects several cell functions. We hypothesized that
hydrogen sulfide modulates high glucose (30 mm) stimulation of matrix protein synthesis in
glomerular epithelial cells. High glucose stimulation of global protein synthesis, cellular
hypertrophy, and matrix laminin and type IV collagen content was inhibited by sodium
hydrosulfide (NaHS), an H 2 S donor. High glucose activation of mammalian target of
rapamycin (mTOR) complex 1 (mTORC1), shown by phosphorylation of p70S6 kinase and …
hydrogen sulfide modulates high glucose (30 mm) stimulation of matrix protein synthesis in
glomerular epithelial cells. High glucose stimulation of global protein synthesis, cellular
hypertrophy, and matrix laminin and type IV collagen content was inhibited by sodium
hydrosulfide (NaHS), an H 2 S donor. High glucose activation of mammalian target of
rapamycin (mTOR) complex 1 (mTORC1), shown by phosphorylation of p70S6 kinase and …