[HTML][HTML] Glycogen synthase kinase 3β is a novel regulator of high glucose-and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular …

MM Mariappan, M Shetty, K Sataranatarajan… - Journal of biological …, 2008 - ASBMB
High glucose (30 mm) and high insulin (1 nm), pathogenic factors of type 2 diabetes,
increased mRNA expression and synthesis of lamininβ1 and fibronectin after 24 h of
incubation in kidney proximal tubular epithelial (MCT) cells. We tested the hypothesis that
inactivation of glycogen synthase kinase 3β (GSK3β) by high glucose and high insulin
induces increase in synthesis of laminin β1 via activation of eIF2Bϵ. Both high glucose and
high insulin induced Ser-9 phosphorylation and inactivation of GSK3β at 2 h that lasted for …