Regulation of renal laminin in mice with type II diabetes
TS Ha, JL Barnes, JL Stewart, CW Ko… - Journal of the …, 1999 - journals.lww.com
This study examines the regulation of renal laminin in the db/db mouse, a model of type II
diabetes characterized by extensive remodeling of extracellular matrix.
Immunohistochemistry demonstrated an increase in the contents of laminin chains including
β1 chain in the mesangium and tubular basement membranes at 1, 2, 3, and 4 mo of
diabetes. Immunofluorescence with an antibody against the recently discovered laminin α5
chain showed that in the normal mouse, the protein had a restricted distribution to the …
diabetes characterized by extensive remodeling of extracellular matrix.
Immunohistochemistry demonstrated an increase in the contents of laminin chains including
β1 chain in the mesangium and tubular basement membranes at 1, 2, 3, and 4 mo of
diabetes. Immunofluorescence with an antibody against the recently discovered laminin α5
chain showed that in the normal mouse, the protein had a restricted distribution to the …