[HTML][HTML] Neutralization and Transfer of Lipopolysaccharide by Phospholipid Transfer Protein (∗)
E Hailman, JJ Albers, G Wolfbauer, AY Tu… - Journal of Biological …, 1996 - ASBMB
Phospholipid transfer protein (PLTP) and lipopolysaccharide-binding protein (LBP) are lipid
transfer proteins found in human plasma. PLTP shares 24% sequence similarity with LBP.
PLTP mediates the transfer and exchange of phospholipids between lipoprotein particles,
whereas LBP transfers bacterial lipopolysaccharide (LPS) either to lipoprotein particles or to
CD14, a soluble and cell-surface receptor for LPS. We asked whether PLTP could interact
with LPS and mediate the transfer of LPS to lipoproteins or to CD14. PLTP was able to bind …
transfer proteins found in human plasma. PLTP shares 24% sequence similarity with LBP.
PLTP mediates the transfer and exchange of phospholipids between lipoprotein particles,
whereas LBP transfers bacterial lipopolysaccharide (LPS) either to lipoprotein particles or to
CD14, a soluble and cell-surface receptor for LPS. We asked whether PLTP could interact
with LPS and mediate the transfer of LPS to lipoproteins or to CD14. PLTP was able to bind …