Macroautophagy (hereafter autophagy) is a lysosomal catabolic pathway that controls
cellular homeostasis and survival. It has recently emerged as an attractive target for the
treatment of a variety of degenerative diseases and cancer. The targeting of autophagy has,
however, been hampered by the lack of specific small molecule inhibitors. Thus, we
screened two small molecule kinase inhibitor libraries for inhibitors of rapamycin-induced
autophagic flux. The three most potent inhibitors identified conferred profound inhibition of …