[HTML][HTML] 14-3-3 Binding to ataxin-1 (ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus

S Lai, B O'Callaghan, HY Zoghbi, HT Orr - Journal of Biological Chemistry, 2011 - ASBMB
Spinocerebellar ataxia type 1 (SCA1) is a lethal neurodegenerative disorder caused by
expansion of a polyglutamine tract in ATXN1. A prominent site of pathology in SCA1 is
cerebellar Purkinje neurons where mutant ATXN1 must enter the nucleus to cause disease.
In SCA1, phosphorylation of ATXN1 at Ser-776 modulates disease. Interestingly, Ser-776 is
located within a region of ATXN1 that harbors several functional motifs including binding
sites for 14-3-3, and splicing factors RBM17 and U2AF65. The interaction of ATXN1 with …