Inducible nitric oxide synthase promotes pathophysiological consequences of experimental bladder outlet obstruction
D Felsen, K Dardashti, M Ostad, ML Lemer… - The Journal of …, 2003 - Elsevier
PURPOSE: Bladder outlet obstruction leads to histological and functional changes in the
bladder over time. We investigated the role of inducible nitric oxide synthase (iNOS) in the
progression of pathological changes of the bladder secondary to outlet obstruction in a rat
and a mouse model. MATERIALS AND METHODS: To assess expression of iNOS in the
bladder, polymerase chain reaction amplification of mRNA was done. Rats were subjected
to sham operation or partial bladder outlet obstruction. They were given the iNOS inhibitor …
bladder over time. We investigated the role of inducible nitric oxide synthase (iNOS) in the
progression of pathological changes of the bladder secondary to outlet obstruction in a rat
and a mouse model. MATERIALS AND METHODS: To assess expression of iNOS in the
bladder, polymerase chain reaction amplification of mRNA was done. Rats were subjected
to sham operation or partial bladder outlet obstruction. They were given the iNOS inhibitor …