Previous molecular and blood flow studies performed on animal models of partial bladder
outlet obstruction (PBOO) caused us to propose that bladder hypoxia/ischemia was a
significant effector of the cellular and functional changes that occur in the bladder as a result
of this condition. To confirm the occurrence of hypoxia in the partially obstructed bladder, we
obtained rat bladders at increasing intervals following PBOO and measured biomarkers of
hypoxia (intracellular formation of hypoxyprobe-1 adducts and expression of hypoxia …