Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms
GZ Ge, TR Xu, C Chen - Acta Biochim Biophys Sin, 2015 - academic.oup.com
GZ Ge, TR Xu, C Chen
Acta Biochim Biophys Sin, 2015•academic.oup.comTobacco usage is a major risk factor in the development, progression, and outcomes for lung
cancer. Of the carcinogens associated with lung cancer, tobacco-specific nitrosamines 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is among the most potent ones. The
oncogenic mechanisms of NNK are not entirely understood, hindering the development of
effective strategies for preventing and treating smoking-associated lung cancers. Here, we
introduce the NNK-induced lung cancer animal models in different species and its potential …
cancer. Of the carcinogens associated with lung cancer, tobacco-specific nitrosamines 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is among the most potent ones. The
oncogenic mechanisms of NNK are not entirely understood, hindering the development of
effective strategies for preventing and treating smoking-associated lung cancers. Here, we
introduce the NNK-induced lung cancer animal models in different species and its potential …
Abstract
Tobacco usage is a major risk factor in the development, progression, and outcomes for lung cancer. Of the carcinogens associated with lung cancer, tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is among the most potent ones. The oncogenic mechanisms of NNK are not entirely understood, hindering the development of effective strategies for preventing and treating smoking-associated lung cancers. Here, we introduce the NNK-induced lung cancer animal models in different species and its potential mechanisms. Finally, we summarize several chemopreventive agents developed from these animal models.
Oxford University Press