Kainic acid selectively alters auditory dendrites connected with cochlear inner hair cells
R Pujol, M Lenoir, D Robertson, M Eybalin… - Hearing research, 1985 - Elsevier
Cochleas of adult guinea pigs and rats, and 6-day-old rat pups, were injected, through the
round window, with 2 μ1 of artificial classical Konishi perilymph containing 1 nmol kainic
acid (KA). 5 min later, they were fixed, removed, and processed for electron microscopy. In
all KA-treated cochleas, the injection resulted in a severe swelling of auditory dendrites
below the inner hair cells (IHCs). Below the outer hair cells (OHCs), the swelling appeared
only in the 6-day-old rats, not in adult animals. These results are significant in three different …
round window, with 2 μ1 of artificial classical Konishi perilymph containing 1 nmol kainic
acid (KA). 5 min later, they were fixed, removed, and processed for electron microscopy. In
all KA-treated cochleas, the injection resulted in a severe swelling of auditory dendrites
below the inner hair cells (IHCs). Below the outer hair cells (OHCs), the swelling appeared
only in the 6-day-old rats, not in adult animals. These results are significant in three different …